Abstract:Based on the interpersonal / systemic modelandthe emotional cascade model, this study examined the relationship between negative life events and self-injury. 684 junior middle school students were recruited to participate in this study, and they anonymously filled out questionnaires regarding Adolescents Self-HarmScale, Adolescent Self-Rating Life Events Check List, Family Adaptability and Cohesion Scale, and Ruminative Responses Scale. The result indicated that: (1) negative life events significantly positively predicted self-injury of the junior middle school students; (2) the relationship between negative life events and self-injury was significantly mediated by rumination; (3) the relationship between rumination and self-injury was moderated by family cohesion. The results provide new ideas for the prevention and intervention of self-injury.